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مدلسازی مبتنی بر عامل درمان التهاب آلرژیک در آسم توسط ترکیبات گیاهی | ||
| مدل سازی در مهندسی | ||
| دوره 24، شماره 85، تیر 1405، صفحه 33-52 اصل مقاله (1.99 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22075/jme.2025.34614.2693 | ||
| نویسندگان | ||
| سولماز نیساری تبریزی؛ اباذر عرب عامری* ؛ سجاد حق زاد کلیدبری | ||
| گروه برق، دانشکده مهندسی، دانشگاه زنجان، زنجان، ایران | ||
| تاریخ دریافت: 09 تیر 1403، تاریخ بازنگری: 13 تیر 1404، تاریخ پذیرش: 04 شهریور 1404 | ||
| چکیده | ||
| آسم یک بیماری پیچیده است که با التهاب مزمن راه هوایی و اختلال در سیستم ایمنی شناخته می شود. محققان در دهههای اخیر مطالعات زیادی بر روی گیاهان دارای اثرات ضد حساسیت و ضد آسم انجام دادهاند. در این مطالعه، یک مدل مبتنی بر عامل برای شبیهسازی تعاملات بین سلولهای ایمنی و بافت ریه در طول التهاب آسم ارائه شده است. برای اولین بار، درمان آسم با داروهای گیاهی در مدل بر اساس دادههای تجربی و مطالعات مدلسازی قبلی وارد شده است. پارامترهای مدل با استفاده از داده های تجربی از مطالعات آزمایشگاهی در مورد درمان آسم با ترکیبات گیاهی تعیین شده است. خروجیهای مدل ارائه شده با دادههای تجربی مطابقت داشته و به خوبی آن ها را تقلید می کند. با استفاده از مدل، ما چندین پدیده مرتبط با درمان آسم را بررسی کرده ایم: (1) تعیین روز بهینه برای شروع درمان، (2) ارزیابی سهم هر مسیر التهابی در سلامت ریه، (3) ارزیابی اثر مسیرهای ضد التهابی بر سلامت بافت ریه، (4) تجزیه و تحلیل حساسیت سراسری و شناسایی پارامترهای مهم در مدل و (5) بررسی اینکه چگونه حذف اثرات دارو بر مسیرهای پیش التهابی و ضد التهابی بر خروجی مدل تأثیر می گذارد. یافتههای این مقاله مطالعات تجربی موجود را تایید کرده و بینشهای ارزشمندی را در مورد درک بیماری زایی آسم و رویکردهای درمانی بالقوه با استفاده از داروهای گیاهی ارائه میکند. | ||
| کلیدواژهها | ||
| التهاب ریه؛ آسم؛ مدلسازی ریاضی؛ معادلات دیفرانسیل؛ مدل مبتنی بر عامل؛ داروی گیاهی | ||
| عنوان مقاله [English] | ||
| Agent-Based Modeling of Herbal Compound Treatment for Allergic Inflammation in Asthma | ||
| نویسندگان [English] | ||
| Solmaz Neisari Tabrizi؛ Abazar Arabameri؛ Sajad Haghzad Klidbary | ||
| Department of Electrical Engineering, Faculty of Engineering, University of Zanjan, Zanjan, Iran | ||
| چکیده [English] | ||
| Asthma is a complex disease characterized by chronic airway inflammation and immune system disorders. Over the years, researchers have explored the potential of plants with anti-allergic and anti-asthmatic properties. In our study, we have developed an agent-based model to simulate the interactions between immune cells and lung tissue during asthma inflammation. This model incorporates the use of herbal medicines as a treatment for asthma, based on both experimental data and previous modeling studies. By estimating the parameters of the model with data from experimental studies on herbal compounds for asthma treatment, we have successfully replicated and simulated outcomes seen in experiments. Our study allows us to delve into various aspects of asthma treatment, including identifying the optimal timing for treatment initiation, assessing the impact of different inflammatory pathways on lung health, and examining the effects of anti-inflammatory pathways. Additionally, we conducted a global sensitivity analysis to pinpoint crucial parameters in the model and explored how removing drug effects on certain pathways affects the model's outputs. Our results not only validate previous experimental studies but also offer valuable insights into asthma pathogenesis and the potential use of herbal medicines as a therapeutic approach. | ||
| کلیدواژهها [English] | ||
| Inflammation, Asthma, Mathematical modeling, Differential equations, Agent-based model, Herbal medicine | ||
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| مراجع | ||
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