Three-component synthesis of new γ-butyrolactones | ||
| شیمى کاربردى روز | ||
| Volume 15, Issue 56, September 2020, Pages 257-266 PDF (1.25 M) | ||
| Document Type: Original Article | ||
| DOI: 10.22075/chem.2020.12695.1245 | ||
| Author | ||
| Leila Zare Fekri* | ||
| payame Noor university | ||
| Receive Date: 21 June 2019, Revise Date: 15 November 2019, Accept Date: 06 October 2020 | ||
| Abstract | ||
| In this research, γ –butyrolactones were prepared using a green, mild, effective and simple method through multi-component synthesis of pyrazole carbaldehyde or indole-3-carbaldehyde, ethylpyruvate and N-bromosuccinimide. The mechanistical pathway for this reaction includes bromination reaction, condensation reaction followed by intra-molecular cyclization. This methodology is completely new and the products were synthesized in short reaction times and high yields. This protocole has advantages as simple method, aqeous media, and reduced environmentally consequences. All of the synthesized compounds were characterized by melting points, infra-red spectroscopy, nuclear magnetic resonance (1H NMR, 13C NMR) and elemental analysis. The novelty of this protocole combined with the novelty of the synthesized compounds is the other highlights of this procedure. | ||
| Keywords | ||
| multicomponent reaction; γ- butyrolactone; ethylpyruvate; N-bromosuccinimide | ||
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