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سنتز و شناسایی نانو اکسید نیکل مغناطیسی برای استخراج فاز جامد مغناطیسی جم فیبروزیل و اندازه گیری آن توسط دستگاه طیف سنج UV-Vis | ||
| شیمى کاربردى روز | ||
| دوره 18، شماره 68، مهر 1402، صفحه 323-342 اصل مقاله (1.34 M) | ||
| نوع مقاله: مقاله علمی پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22075/chem.2023.29235.2127 | ||
| نویسندگان | ||
| نرگس صالحی؛ علی مقیمی* | ||
| دانشگاه علوم پزشکی آزاد اسلامی تهران، دانشکده شیمی دارویی، گروه شیمی، تهران، ایران، صندوق پستی1913674711 | ||
| تاریخ دریافت: 30 آذر 1401، تاریخ بازنگری: 29 بهمن 1401، تاریخ پذیرش: 15 فروردین 1402 | ||
| چکیده | ||
| درروش ارائه‌شده، نانواکسید نیکل مغناطیسی اصلاح‌شده برای پیش تغلیظ و اندازه‌گیری جم فیبروزیل در نمونه‌های سرم انسانی، فاضلاب‌های دارویی و دارو سنتز و شناسایی شد. طیف تبدیل فوریه مادون‌قرمز (FTIR)، پراش اشعه ایکس(XRD) و میکروسکوپ الکترونی روبشی(SEM) برای شناسایی نانو اکسید نیکل مغناطیسی استفاده شدند. برخی از پارامترهای مؤثر بر استخراج ازجمله اثر pH، مقدار و نوع حلال شوینده، زمان استخراج و... بهینه و بررسی شدند. فاکتور تغلیظ 120 ، مقدار حد تشخیص روش(LOD) 01/0 میکروگرم بر لیتر و رنج خطی منحنی کالیبراسیون 05/0 تا 1000 میکروگرم بر لیتر به دست آمد. ظرفیت جاذب 69/52 میلی‌گرم بر گرم به دست آمد. این روش برای اندازه‌گیری جم فیبروزیل در نمونه‌های سرم انسانی، فاضلاب‌های دارویی و دارو با استفاده از دستگاه طیف‌سنجی UV-Vis با بازیابی در محدوده 0/98-0/104٪ با موفقیت بکار گرفته شد. سپس نمونه‌های اندازه‌گیری شده توسط روش پیشنهادی با نتایج حاصل از روش استاندارد کروماتوگرافی مایع با کارایی بالا (HPLC) موردقیاس قرار داده شد. نتایج با آزمون T-test بررسی شد و نشان داد که هیچ‌گونه اختلاف معناداری بین دو روش وجود ندارد. | ||
| کلیدواژه‌ها | ||
| اصلاح اکسید نیکل؛ جم فیبروزیل؛ استخراج فاز جامد مغناطیسی؛ جذب سطحی | ||
| عنوان مقاله [English] | ||
| Synthesis and identification of magnetic nickel oxide nanoparticles for the magnetic solid phase extraction of gemfibrozil and its determination by UV-Vis spectrometer. | ||
| نویسندگان [English] | ||
| Narges Salehi؛ ali moghimi | ||
| Tehran Islamic Azad University of Medical Sciences, Faculty of Medicinal Chemistry, Department of Chemistry, Tehran, Iran, PO Box: 1913674711 | ||
| چکیده [English] | ||
| In the presented method, modified magnetic nickel oxide was synthesized and identified for pre-concentration and determination of gemfibrozil in human serum samples, pharmaceutical wastewater and drug. Fourier transform infrared spectrum (FTIR), X-ray diffraction (XRD) and scanning electron microscope (SEM) were used to identify magnetic nickel oxide nanoparticles. Some parameters affecting the extraction, including pH effect, amount and type of elution solvent, extraction time, etc., were optimized and investigated. The concentration factor was 120, the limit of detection (LOD) was 0.16 µg.L-1, and the linear range of the calibration curve was 0.05 to 10 µg.L-1. The adsorption capacity was 52.69 mg.g-1. This method was successfully used to determination of gemfibrozile in human serum samples, pharmaceutical wastewater and drug using UV-Vis spectrometer with recovery in the range of 0.98-0.104%. Then, the samples determined by the proposed method with the results of the standard high-performance liquid chromatography (HPLC) method were compared. The results were checked with T-test and showed that there is no significant difference between the two methods. | ||
| کلیدواژه‌ها [English] | ||
| modification of nickel oxide, gemfibrozil, magnetic solid phase extraction, adsorption | ||
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| مراجع | ||
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