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تعیین الکتروشیمیایی داروی دوپامین در سطح الکترود خمیر کربن اصلاحشده با نانوکامپوزیت نیکل-نانولولههای کربنی چندجداره و نانوذرات تیتانیوم دیاکساید | ||
| شیمى کاربردى روز | ||
| دوره 19، شماره 70، فروردین 1403، صفحه 293-312 اصل مقاله (1015.2 K) | ||
| نوع مقاله: مقاله علمی پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22075/chem.2024.26109.2049 | ||
| نویسندگان | ||
| الهام رسولی1؛ مصطفی رحیم نژاد* 2؛ هدی ازوجی1 | ||
| 1مرکز تحقیقات سوخت های زیستی و انرژی های تجدیدپذیر، گروه بیوتکنولوژی، دانشکده مهندسی شیمی، دانشگاه صنعتی نوشیروانی بابل، ایران | ||
| 2مرکز تحقیقات سوخت های زیستی و انرژی های تجدیدپذیر، گروه بیوتکنولوژی، دانشکده مهندسی شیمی، دانشگاه صنعتی نوشیروانی بابل، ایران | ||
| تاریخ دریافت: 23 بهمن 1400، تاریخ بازنگری: 29 اسفند 1401، تاریخ پذیرش: 24 اردیبهشت 1403 | ||
| چکیده | ||
| در این کار تحقیقاتی، یک حسگر الکتروشیمیایی ساده و گزینشپذیر با حساسیت بالا برای تعیین داروی دوپامین پیشنهاد شد. برای این منظور، از یک نانوکامپوزیت متشکل از نیکل- نانولولههای کربنی چندجداره و نانوذرات تیتانیومدیاکساید برای اصلاح الکترود خمیرکربن استفاده شد. مورفولوژی سطح حسگر اصلاحشده توسط میکروسکوپ الکترونی روبشی گسیل میدانی (FESEM) و طیفسنجی مادون قرمز تبدیل فوریه (FTIR) ارزیابی شد. روشهای ولتامتری چرخهای (CV)، ولتامتری پالس تفاضلی (DPV) و طیفسنجی امپدانس الکتروشیمیایی (EIS) برای تجزیه و تحلیل رفتار الکتروشیمیایی الکترود اصلاحشده پیشنهادی و تعیین خصوصیات الکتروشیمیایی دوپامین به کار رفتند. الکترود اصلاحشده بهکاررفته در این پژوهش یک پاسخ الکترواکسیداسیون عالی به حضور دوپامین نشان داد. علاوهبراین، برای بهینهسازی پاسخ حسگر الکتروشیمیایی، هر گونه تغییر در رفتار ولتامتری دوپامین تحت شرایط pH و سرعتهای روبش مختلف مورد بررسی قرار گرفت. تحت شرایط بهینه، جریان پیک الکتروکاتالیستی دوپامین، به غلظت دوپامین در محدوده µM 100- 3/0 بهصورت خطی وابسته بوده و حد تشخیص nM 68/11 برای آن محاسبه شد. همچنین، پارامترهای الکتروشیمیایی مانند تعداد الکترونهای منتقلشده و ضریب انتقال الکترون نیز برآورد شدند. یافتههای مطالعه حاضر نشان دادند که حسگر موردنظر دارای حساسیت بالا، حد تشخیص کم، پاسخ سریع، پایداری طولانیمدت، قابلیت تکرارپذیری و تجدیدپذیری قابلتوجه، گزینشپذیری و بازیابی بالا و همچنین، عملکرد عالی در تشخیص آنالیت در نمونههای حقیقی است که ثابت میکند الکترود پیشنهادی، برای کاربردهای صنایع غذایی، پزشکی و زیستمحیطی کاملاً قابل استفاده میباشد. روش پیشنهادی ساده، سریع و ارزان است و میتواند به عنوان یک ابزار تحلیلی ارزشمند در کنترل کیفیت صنعت داروسازی مورد استفاده قرار گیرد. | ||
| کلیدواژهها | ||
| حسگر الکتروشیمیایی؛ دوپامین؛ الکترود خمیرکربن؛ نانوکامپوزیت؛ نانولولههایکربنی چندجداره؛ نانوذرات تیتانیومدیاکساید | ||
| عنوان مقاله [English] | ||
| Electrochemical determination of dopamine at the surface of carbon paste electrode modified with Ni-MWCNT/TiO2NPs nano-composite | ||
| نویسندگان [English] | ||
| Elham Rasouli1؛ Mostafa Rahimnejad2؛ Hoda Ezoji1 | ||
| 1Biofuel and Renewable Energy Research Center, Department of Chemical Engineering, Babol Noshirvani University of Technology, Babol, Iran. | ||
| 2Biofuel and Renewable Energy Research Center, Department of Chemical Engineering, Babol Noshirvani University of Technology, Babol, Iran. | ||
| چکیده [English] | ||
| In this research, a simple and selective electrochemical sensor with high-sensitivity was proposed to detect dopamine. For this purpose, a nanocomposite consist of nickel-multiwalled carbon nanotubes and titanium dioxide nanoparticles was used to modify the carbon paste electrode. The surface morphology of the modified sensor was evaluated by field emission scanning electron microscopy (FESEM) and Fourier transform infrared spectrometry (FTIR). Cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) techniques were used to analyze of the proposed modified electrode electrochemical behavior and to characterize dopamine. The modified electrode used in this study showed an excellent electro-oxidation response to the presence of dopamine. In addition, to optimize the electrochemical sensor response, any change in the voltammetric behavior of dopamine under different pH and scan rates conditions were investigated and phosphate buffer solution was used for this purpose. Under optimal conditions, the dopamine electrocatalytic peak currents are linearly dependent on the dopamine concentration in the range of 0.3-100 µM and the detection limit of 11.68 nM was calculated for it. Also, electrochemical parameters such as the transferred electrons number and the electron transfer coefficient were estimated. The present study findings showed that the sensor has high sensitivity, low detection limit, fast response, long-term stability, significant repeatability and reproducibility, high selectivity and recovery, as well as excellent performance in analyt detection in the real samples, which proves that the proposed electrode can be used in food, medical and environmental applications. The proposed method is simple, fast and inexpensive and can be used as a valuable analytical tool in quality control of the pharmaceutical industry. | ||
| کلیدواژهها [English] | ||
| Electrochemical sensor, dopamine, carbon paste electrode, nanocomposite, multiwalled carbon nanotubes, titanium dioxide nanoparticles | ||
| مراجع | ||
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آمار تعداد مشاهده مقاله: 472 تعداد دریافت فایل اصل مقاله: 483 |
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