پیوندهای مفید
آمار
| تعداد نشریات | 21 |
| تعداد شماره‌ها | 664 |
| تعداد مقالات | 9,694 |
| تعداد مشاهده مقاله | 69,028,635 |
| تعداد دریافت فایل اصل مقاله | 48,497,497 |
مدل‌سازی اثرCEST از طریق تشدید مغناطیسی برای تعیین همزمان نرخ تبادل شیمیایی و غلظت آمین و آمید در بدن انسان | ||
| مدل سازی در مهندسی | ||
| دوره 23، شماره ویژه 81، تیر 1404، صفحه 221-233 اصل مقاله (672.04 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22075/jme.2024.34017.2660 | ||
| نویسنده | ||
| محمد رضا رضاییان* | ||
| گروه مهندسی پزشکی، دانشگاه صنعتی همدان، همدان، ایران | ||
| تاریخ دریافت: 14 اردیبهشت 1403، تاریخ بازنگری: 08 آبان 1403، تاریخ پذیرش: 12 آبان 1403 | ||
| چکیده | ||
| انتقال اشباع منجر به جابجایی هیدروژن‌های آب و مولکول‌های بافت‌های بدن از طریق اعمال پالس اشباع الکترومغناطیسی به رشته پالس تصویربرداری اسکنر تشدید مغناطیسی می‌شود. اثر CEST حاصل از تبادل مابین عامل‌های کنتراست درونی یا بیرونی با آب موجود در بدن، یکی از زیربخش‌های فرآیندهای تبادل شیمیایی محسوب می‌شود. اثر CEST به عواملی همچون زمان‌های استراحت، نرخ تبادل شیمیایی، غلظت عامل کنتراست و ویژگی‌های پالس اشباع الکترومغناطیسی بستگی دارد. از این عوامل می‌توان به اطلاعاتی از نحوه تعامل شیمیایی، آنزیم‌ها، متابولیت‌ها، یون‌های فلزی، pH، مصرف گلوکز و دیگر شرایط بالینی دست یافت. این مقاله روابطی تحلیلی برای تعیین نرخ تبادل شیمیایی و غلظت عامل کنتراست از طریق مدل‌سازی اثر CEST به عنوان تابع هدف با استفاده از نمودار امگا تعیین می‌کند.علاوه بر آن با محاسبه دامنه بهینه پالس الکترومغناطیسی مستطیلی از طریق بیشینه‌سازی تابع هدف محدب‌گونه پیشنهادی اثرCEST، مجددا نرخ تبادل شیمیایی و غلظت عامل کنتراست مورد ارزیابی قرار می‌گیرد. ارزیابی نتایج دو راهکار پیشنهادی با استفاده از داده‌های پارامتری دوحوضچه‌ای آمید-آب و آمین-آب از طریق مقایسه با دو بیان دیگر از اثر CEST که مورد استناد مطالعات متعددی بوده نیز انجام گرفته است. نمودارهای امگا حاصله از مدل‌سازی پیشنهادی اثرCEST ، بهترین انطباق در تعیین نرخ تبادل و غلظت را برای ترکیب آب-آمین بر اساس کمترین درصد خطای نسبی، حدودا 5/0% و 8/4% به ترتیب بوده است. از طرفی بر مبنای روش تعیین دامنه بهینه، بهترین تطابق در تخمین نرخ تبادل و غلظت به ترتیب با دقت 91% و 100%، در آمیدها حاصل شده است. | ||
| کلیدواژه‌ها | ||
| انتقال اشباع؛ عامل کنتراست؛ مدل‌سازی اثر CEST؛ نرخ تبادل شیمیایی | ||
| عنوان مقاله [English] | ||
| Modeling of the Cest Effect for Determining Chemical Exchange Rate and Concentration of Amine and Amide in the Human Through Magnetic Resonance Simultaneously | ||
| نویسندگان [English] | ||
| Mohammad Reza Rezaeian | ||
| Biomedical Engineering Department, Hamedan University of Technology, Hamedan, Iran | ||
| چکیده [English] | ||
| The saturation transfer leads to exchange between hydrogens of water and hydrogens of molecules tissue by applying radio frequency (RF) saturation pulse to the sequence of the magnetic resonance imaging. The CEST effect, which occurs between water protons and exogeneous or endogeneous contrast agents, is considered one of the important subsections of the set of chemical exchange saturation transfer processes. The CEST effect mainly depends on relaxation times, chemical exchange rate, contrast agent concentration and characteristics of the RF saturation pulse. Based on these factors, can be obtained important information from chemical interactions, enzymes, metabolites, metal ions, pH, glucose consumption and other clinical conditions. In this article, chemical exchange rate and contrast agent concentration are determined quantitatively through the Omega-plot by computing the CEST effect.In addition, the chemical exchange rate and concentration are determined through the optimal amplitude RF rectangular at the maximum of the proposed CEST effect as goal function.The evaluation of two proposed approaches has been done using two sets of parametric data, amide-water and amine-water, and two other definitions of the CEST as a comparison with the reference definition.The Omega-plots are calculated for each parametric data based on different definitions of CEST effect, the good agreement is for water-amine through minimum relative sum square error, about 0.5% and 4.8% compared to the reference definition. On the other hand based on optimizing reference definition of the CEST, the best agreement is for water-amid, through estimating the chemical exchange rate and contrast agent concentration about 91% and 100% respectively. | ||
| کلیدواژه‌ها [English] | ||
| Saturation transfer, Contrast agent, CEST effect modeling, Chemical exchange rate | ||
| مراجع | ||
|
[1] A. Sadet, C. Stavarache, F. Teleanu, and P. Vasos. "Water hydrogen uptake in biomolecules detected via nuclear magnetic phosphorescence. "Sci. Rep 9, no. 1 (2019): 1-7. [2] W. Dou, C.E. lin, H. Ding, Y. Shen, C. Dou, L. Qian, B. Wen, and B. Wu. "Chemical exchange saturation transfer magnetic resonance imaging and its main and potential applications in pre-clinical and clinical studies. " Quant Imaging Med Surg 9, no. 10 (2019): 1747-1766. [3] P.V. Zijl, W. Lam, J. Xu, L. Knutsson, and G.J. Stanisz. "Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum. " Neuroimage 168, (2018): 222-241. [4] J. Kim, Y. Wu, Y. Guo, H. Zheng, and P.Z. Sun. "A review of optimization and quantification techniques for chemical exchange saturation transfer MRI toward sensitive in vivio imaging. " Contrast Media Mol Imaging 10, no. 3 (2015): 163-178. [5] E. Vinogradov, A. Sherry, and R.E. Lenkinski. "CEST: from basic principles to applications, challenges and opportunities." Journal of Magnetic Resonance 229, (2013): 155-172. [6] M. Zaiss, and P. Bachert. "Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods." Phys. Med. Biol 58, no. 22 (2013): 221-269. [7] M.R. Rezaeian. "Analytical determination of the chemical exchange saturation transfer (CEST) contrast in molecular magnetic resonance imaging." Signal and Data Processing 17, no. 3 (2020): 71-86. (in Persian) [8] Y. Tang, G. Xiao, Z. Shen, C. Zhuang, Y. Xie, X. Zhang, Z. Yang, J. Guan, Y. Shen, Y. Chen, L. Lai, Y. Chen, S. Chen, Z. Dai, R. Wang, and R. Wu. "Noninvasive detection of extracellular pH in human benign and malignant liver tumors using CEST MRI." Frontiers in Oncology 10, (2020): 1-10. [9] L.R. Lindeman, E.A. Randtke, R.A. High, K.M. Jones, C.M. Howison, and M.D. Pagel. "A comparison of exogenous and endogenous CEST MRI methods for evaluating in vivo pH." Magnetic Resonance in Medicine 79, no. 5 (2018): 2766-2772. [10] P.Z. Sun, G. Xiao, I.Y. Zhou, Y. Guo, and R. Wu. "A method for accurate pH mapping with chemical 1 exchange saturation transfer (CEST) MRI. " Contrast Media Mol Imaging 11, no. 3 (2016): 195-202. [11] J. Zhou, H.Y. Heo, L. Knutsson, P.V. Zijl, and S. Jiang. "APT-weighted MRI: Techniques, current neuro applications, and challenging issues." Journal of Magnetic Resonance 50, no. 2 (2019): 347-364. [12] Y. Zheng, and X. Wang. "The Applicability of Amide Proton Transfer Imaging in the Nervous System: Focus on Hypoxic-Ischemic Encephalopathy in the Neonate. " Cell Mol Neurobiol 38, no. 4 (2018): 797-807. [13] H. Heo, Y. Zhang, D.H. Lee, X. Hong, and J. Zhou. "Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semi-solid magnetization transfer reference (EMR) signals: Application to a rat glioma model at 4.7 Tesla." Magnetic Resonance in Medicine 75, no. 1 (2016): 137-149. [14] M.R. Rezaeian. "Simultaneous determination of exchange rate and concentration of paramagnetic contrast agent in magnetic resonance imaging using electromagnetic pulse width." Journal of Machine Vision and Image Processing 8, no. 4 (2021): 1-11. (in Persian) [15] M. McMahon, A. Gilad, j. Zhou, P.Z. Sun, and P.V. Zijl. "Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal." Magnetic Resonance in Medicine 55, (2016): 836-847. [16] E.A. Randtke, M.D. Pagel, and J.C. Rodriguez. "QUESPOWR MRI: QUantification of exchange as a function of saturation power on the water resonance." Journal of Magnetic Resonance 270, (2016): 56-70. [17] M. Zaiss, G. Angelovski, E. Demetriou, M. McMahon, X. Golay, and K. Scheffler. "QUESPand QUEST Revisted-Fast and Accurate Quantitative CEST experiments." Magnetic Resonance in Medicine 79, no. 3 (2018): 1708-1721. [18] E. Demetriou, M. Tachrount, M. Zaiss, and X. Golay. "PRO-QUEST: a rapid assessment method based on progressive saturation for quantifying exchange rates using saturation times in CEST." Magnetic Resonance in Medicine 80, no. 4 (2018): 1638-1654. [19] M. Kim, A. Kujawa, M. Battiston, E. Demetriou, T. Schneider, S. Collorone, C. Tur, V. Evans. S. Okuchi, D. Atkinson, C. Gandini, and X. Golay. "Translating pH-sensitive PROgressive saturation for Quantifying Exchange rates using Saturation Times (PRO-QUEST) MRI to a 3T clinical scanner. " Magnetic Resonance in Medicine 84, no. 4 (2020): 1734-1746. [20] H. Heo, Z. Han, S. Jiang, M. Schar, P.V. Zijl, and J. Zhou. "Quantifying amide proton exchange rate and concentration in chemical exchange saturation transfer imaging of the human brain." Neuroimage 189 , (2019): 202-213. [21] P.Z. Sun. "Simultaneous determination of labile proton concentration and exchange rate utilizing optimal RF power: radio frequency power (RFP) dependence of chemical exchange saturation transfer (CEST) MRI." Journal of Magnetic Resonance 202, no. 2 (2010): 155-161. [22] P.Z. Sun. "Quasi–steady-state CEST (QUASS CEST) solution improves the accuracy of CEST quantification: QUASS CEST MRI-based omega plot analysis." Magnetic Resonance in Medicine 86, no. 2 (2021): 765-776. [23] R. wU, G. Xiao, Y. Zhou, C. Run, P.Z. Sun. "Quantitative chemical exchange saturation transfer (qCEST) MRI – omega plot analysis of RF-spillover-corrected inverse CEST ratio asymmetry for simultaneous determination of labile proton ratio and exchange rate." NMR Biomed 28, no. 3 (2015): 376-383. [24] W. Dixon, J. Ren, J. Lubag, A. Ratnakar, E. Vinogradov, I. Hancu, R. Lenkinski, and A. Sherry. "A concentration-independent method to measure exchange rates in PARACEST agents." Magnetic Resonance in Medicine 63, no. 3 (2010): 625–632. [25] P.Z. Sun, Y. Wang, G. Xiao, and R. Wu, "Quantitative chemical exchange saturation transfer (qCEST) MRI—RF spilover effect-corrected omega plot for simultaneous determination of labile proton fraction ration and exchange rate." Contrast Media Mol Imaging 9, no.4 (2014): 268-275. [26] J.E. Meissner, S. Goerke, E. Rerich, K.D. Klika, A. Radbruch, M.E. Ladd, P. Bachert, and M. Zaiss. "Quantitative pulsed CEST–MRI using omega plots." NMR in Biomedicine 28, no. 10 (2015): 1196-1208. [27] T. Jin, and S. Kim. "Approximated analytical characterization of the steady-state chemical exchange saturation transfer (CEST) signal." Magnetic Resonance in Medicine 82, no. 5 (2019): 1876-1889. [28] M.R. Rezaeian. "Detecting the CEST Effect through the Noisy Z-Spectrum based on Solving the Bloch-McConnell Equations." Iranian Journal of Biomedical Engineering 15, no. 1 (2021): 47-58. (in Persian) [29] M.R. Rezaeain, G.A. Hosien-Zadeh, and H. Soltanian-Zadeh. "Simultaneous optimization of power and duration of radio-frequency pulse in PARACEST MRI." Magnetic Resonance Imaging 34, no. 6 (2016): 743-753. [30] B. Schmitt, M. Zaiß, J. Zhou, and P. Bachert. "Optimization of pulse train presaturation for CEST imaging in clinical scanners. " Magnetic Resonance in Medicine 65, no. 6 (2011): 1620–1629. [31] M.R. Rezaeian. "Determining Chemical Exchange Rate of the CEST Contrast Agents in the Molecular Magnetic Resonance Imaging at the Steady-State Conditions." Iranian Journal of Biomedical Engineering 16, no. 4 (2023): 281-294. (in Persian) [32] S.H. Shin, M.F. Wendland, B. Zhang, A. Tran, A. Tang, and M. H. Vandsburger. "Noninvasive imaging of renal urea handling by CEST-MRI. " Magnetic Resonance in Medicine 83, no. 3 (2019): 1034-1044. [33] F. Talebi, D. Rahimyarharis, E. Asadian. "A Thermal Modeling of Human Tissue for Predicting the Growth of a Tumor." Journal of Modeling in Engineering 7, no. 16 (2009): 45-53. (in Persian) [34] M. Rahim Nejhad, B. Vahidi, B. Ebrahimi, F. Yazdian. " Molecular dynamics simulation of interaction of the anti-cancer drug paclitaxel with the cell membrane: investigation of changes in van der Waals energy and center of mass." Journal of Modeling in Engineering 17, no. 57 (2019): 15-25. (in Persian) | ||
|
آمار تعداد مشاهده مقاله: 230 تعداد دریافت فایل اصل مقاله: 119 |
||