A Comprehensive Study on the Synthesis, Nonlinear Optical Properties, and Biological Applications of Substituted Piperazine Derivatives | ||
| Progress in Physics of Applied Materials | ||
| دوره 6، شماره 4 - شماره پیاپی 13، زمستان 2026، صفحه 343-357 اصل مقاله (1.3 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22075/ppam.2026.40640.1208 | ||
| نویسندگان | ||
| Sahaya Infant Lasalle B* ؛ Senthil Pandian Muthu؛ Ramasamy P | ||
| Department of Physics, SSN Research Centre, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam – 603110, Tamil Nadu, India | ||
| چکیده | ||
| Piperazine is an important organic heterocyclic compound featuring a six-membered ring with two nitrogen atoms positioned opposite each other and four carbon atoms. This moiety is present in numerous widely recognized drugs with diverse therapeutic applications, including antipsychotics, antihistamines, antianginal agents, antidepressants, anticancer agents, antivirals, cardioprotective agents, anti-inflammatory drugs, and imaging agents. In addition to members of the thiazole, benzimidazole, and tetrazole families, certain piperazine analogues also exhibit notable pharmacophoric activities. Consequently, many synthesized derivatives exhibit considerable antimicrobial and antifungal properties. This article describes the growth and characterization of piperazine derivative single crystals, which were analyzed using several techniques to evaluate their potential nonlinear optical applications, including structural analysis (single-crystal X ray diffraction), optical studies (UV–Vis–NIR spectroscopy), and Z scan measurements (third harmonic generation), as well as their biological activities, such as anthelmintic, antitumor, anti-inflammatory, and antimycobacterial activities. | ||
| کلیدواژهها | ||
| Piperazine؛ Single Crystals؛ Single Crystal X-ray diffraction؛ Third harmonic generation | ||
| مراجع | ||
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