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بررسی رفتار دارورسانی لیپوزوم آلیسین بر پایه فسفاتیدیل اتانول آمین و هیدروژل برپایه ثعلب | ||
| شیمى کاربردى روز | ||
| دوره 18، شماره 67، تیر 1402، صفحه 107-124 اصل مقاله (1.28 M) | ||
| نوع مقاله: مقاله علمی پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22075/chem.2022.26440.2056 | ||
| نویسندگان | ||
| رومیصا محمدقلی نژاد1؛ نوشین قلی پور زنجانی* 2؛ آرش کامران پیرزمان1؛ بهزاد زاهد3 | ||
| 1گروه مهندسی شیمی، دانشگاه علم و فناوری مازندران، بهشهر، ایران | ||
| 2گروه پتروشیمی و پلیمر، پژوهشگاه استاندارد، البرز، ایران | ||
| 3گروه مهندسی شیمی، دانشگاه آزاد اسلامی واحد آیت الله آملی، آمل، ایران | ||
| تاریخ دریافت: 21 فروردین 1401، تاریخ بازنگری: 30 مهر 1401، تاریخ پذیرش: 22 آذر 1401 | ||
| چکیده | ||
| در این تحقیق پوشش لیپوزوم بر پایه فسفاتیدیل اتانول آمین ( با روش بنگهام) و هیدروژل بر پایه ثعلب، با هدف بررسی ماندگاری داروی آلیسین تولید و بارگذاری شدند. ساختار لیپوزوم وهیدروژل با FT-IR و SEM بررسی شدند. با در نظر گرفتن متغیرهای نسبت فسفاتیدیل اتانول آمین به کلسترول، نسبت حلال فاز آلی به حلال فاز آبی و زمان تشکیل لیپوزوم، یک مدل جهت پیش‌بینی بازده کپسوله‌سازی آلیسین در لیپوزوم ارائه شد. شرایط بهینه میزان فسفاتیدیل اتانول آمین به کلسترول 8:1، نسبت فاز آلی- فازآبی 1 :8/4 و زمان تشکیل min158 با استفاده از روش سطح پاسخ و نرم‌افزار دیزاین اکسپرت 12 پیش‌بینی شد که منجر به بازده 99/98 % می‌شود. برای پوشش هیدروژل با پایه ثعلب مقدار بیشینه کپسوله‌سازی 98/74% در زمان تشکیل min140، میزان آکریلیک اسید ml3 و میزان N،N’ - متیلن‌بیس‌آکریل‌آمید g01/0 بدست آمد. روند رهایش آلیسین از پوشش لیپوزوم و هیدروژل نشان داد که هردو پوشش می‌توانند کاربری مناسبی برای انتقال دارو در شرایط محیطی با pH حدود 7.4 داشته باشند. بررسی سینتیک انتشار آلیسین از لیپوزوم و هیدروژل براساس مدل‌های واکنش درجه اول، مدل هیگوچی و معادله هیکسون-کراول و مدل ویبول نشان داد که رفتار رهایش آلیسین از این دو پوشش به مدل ویبول نزدیکتر است. | ||
| کلیدواژه‌ها | ||
| آلیسین؛ لیپوزوم؛ هیدروژل؛ ثعلب؛ کپسوله سازی؛ کنترل رهایش | ||
| عنوان مقاله [English] | ||
| Evaluation of drug delivery of allicin liposome based on phosphatidylethanolamine and salep-based hydrogel | ||
| نویسندگان [English] | ||
| Romisa Mohammad Gholinezhad1؛ Nooshin Gholipour Zanjani2؛ Arash Kamran Pirzaman1؛ Behzad Zahed3 | ||
| 1Department of Chemical Engineering, University of Science and Technology of Mazandaran, Behshahr, Iran | ||
| 2Chemistry and Petrochemistry Research Center, Standard Research Institute, Iran | ||
| 3Department of Chemical Engineering, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran | ||
| چکیده [English] | ||
| In this study, liposome coatings based on phosphatidylethanolamine (by Bingham method) and hydrogel based on salep were produced and loaded with the aim of allicin shelf life study. The structure and morphology of Liposome and hydrogel were studied by FT-IR and SEM. Considering design variables of phosphatidylethanolamine to cholesterol ratio, organic phase solvent to aqueous solvent ratio and liposome formation time, a model was proposed to predict the allicin encapsulation efficiency in liposomes. The optimum condition was achieved by Response Surface Method and software of Design-Expert v.12 where the amount of phosphatidylethanolamine-to-cholesterol 8:1, organic phase to water phase ratio of 4.8:1 and formation time of 158 minutes lead to a yield of 98.99%. For salep-based hydrogel coatings, the maximum encapsulation value was 74.98% at 140 min formation time, while the amount of acrylic acid was 3 ml and the amount of N, N '- methylenebisacrylamide was 0.01 gr. The release behavior of allicin from the liposome coating and the hydrogel coating showed both of them are suitable for drug delivery in the media with pH of 7.4. Investigation of allicin release kinetics from liposomes and hydrogels based on first-order reaction models, Higuchi model and Hixson-crowell equation and Weibull model indicated that Weibull can better fit the experimental data. | ||
| کلیدواژه‌ها [English] | ||
| Allicin, Liposome, Hydrogel, Salep, Encapsulation, Released Control | ||
| مراجع | ||
|
[1] Z. Hassanzadeh, E. Mikaeili Agah, A. Asadi and B.v. Kobra, (2019) Effect of aquatic garlic (Allium sativum L. ) extract on the survival of breast cancer cells (MCF-7) and non-cancerous cells of mouse fibroblasts (L929). J. Dev. Biol. 11(1) 45-52.
[2] S. Ejaz, L.C. Woong and A. Ejaz, (2003) Extract of garlic (Allium Sativum) in cancer chemoprevention. Exp. Oncol. 25 93-97.
[3] A. Rabinkov, T. Miron, L. Konstantinovski, M. Wilchek, D. Mirelman and L. Weiner, (1998) The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochimica et Biophysica Acta (BBA) - General Subjects, 1379, 233-244.
[4] H. Shirzad, F. Taji and M. Rafieian, (2011) The Effect of Heating on Useful Components of Garlic. Armaghan Danesh, 16, 9-20.
[5] Q. An, S. Zhao, C. Zhao, R. Wei, L. Zhang, J. Li, Y. Bao, L. Zhang and J. Zheng, (2022). Identification of the key emulsifying components from the byproducts of garlic oil distillation. Food Hydrocolloids, 122, 107043.
[6] Y. Shan, D. Chen, B. Hu, G. Xu, W. Li, Y. Jin, X. Jin, X. Jin and L. Jin, (2021), Allicin ameliorates renal ischemia/reperfusion injury via inhibition of oxidative stress and inflammation in rats. Biomedicine & Pharmacotherapy, 142, 112077.
[7] D. Savaghebi, M. Barzegar and M.R. Mozafari, (2019), Manufacturing of nanoliposomal extract from Sargassum boveanum algae and investigating its release behavior and antioxidant activity. Food science & nutrition, 8 , 299-310.
[8] C.M.B. Pinilla, N.A. Lopes and A. Brandelli, (2021) Lipid-Based Nanostructures for the Delivery of Natural Antimicrobials. Molecules (Basel, Switzerland), 26, 3587.
[9] F. Nobakht Asl and M. Kurdtabar, (2017) Synthesis and Characterization of Iron Magnetic Nanocomposite Super-Absorbent Hydrogels Based on Modified Xanthan Gum using Acrylic Acid. Iranian Journal of Chemistry & Chemical Engineering, 35, 33-38, (in persian).
[10] R. Yusaf, R. Nawaz, S. Hayat, A. Khursheed, N. Zafar, A. Ahmad, I. Bashir, N. Alvi, M. Sajid and I. Majeed, (2014) Structural Components of Liposomes and Characterization Tools. American Journal of Pharm Research, 4, 3559.
[11] T.M. Taylor, J. Weiss, P.M.Davidson and B.D. Bruce, (2005) Liposomal Nanocapsules in Food Science and Agriculture. Critical Reviews in Food Science and Nutrition, 45, 587-605.
[12] M. Babaee, S. Hajivand, and S. Rahman, (2020), Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques. Pharmaceutics, 17-62, 21.
[13] S. Zarei, G. Rezanejade Bardajee and M. Sadeghi, (2019), Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems. Iranian Journal of Chemistry and Chemical Engineering (IJCCE), (IJCCE). 38, 31 (in persian).
[14] G. Rezanejade Bardajee, A. Monfared and M.R. Rezaei, (2022) Synthesis and Characterization of a magnetic multi walled carbon nanotubes nanocomposite hydrogel based on poly(2-dimethylamino) ethyl methacrylate) grafted onto sodium alginate. Journal of Applied Chemistry, 16, 9-24 (in persian).
[15] G. Rezanejade Bardajee and S.S. Hosseini, (2020) Synthesis of Iron Nanocomposite Hydrogel and Study the Release of Doxorubicin Anticancer Drug. Iranian Journal of Chemistry & Chemical Engineering, 38, 67-78 (in persian).
[16] R. Soleyman, G. Bardajee, A. Pourjavadi, A. Varamesh and A. Davoodi, (2015) Hydrolized Salep/GELATIN-G-POLYACRYLAMIDE AS A NOVEL MICRO/NANO-POROUS SUPERABSORBENT HYDROGEL: SYNTHESIS, OPTIMIZATION AND INVESTIGATION ON SWELLING BEHAVIOR. Scientia Iranica,. 22, 883-893 (in persian).
[17] H. Jiang, Z. Xing, Y. Wang, Z. Zhang, B. Kumah Mintah, M. Dabbour, Y. Li, R. He, L. Huang and H. Ma, (2020) Preparation of allicin-whey protein isolate conjugates: Allicin extraction by water, conjugates’ ultrasound-assisted binding and its stability, solubility and emulsibility analysis. Ultrasonics Sonochemistry, 63 , 104981.
[18] Q. Lu, P.-M. Lu, J.H. Piao, X.-L. Xu, J. Chen, L. Zhu and J.-G. Jiang, (2014) Preparation and physicochemical characteristics of an allicin nanoliposome and its release behavior. LWT - Food Science and Technology, 57, 686.-695
[19] A. Pourjavadi, R. Soleyman and G. Bardajee, (2008) Novel Nanoporous Superabsorbent Hydrogel Based on Poly(acrylic acid) Grafted onto Salep: Synthesis and Swelling Behavior. Starch 60 , 467-475.
[20] Q. Lu, P.-M. Lu, J.-H. Piao, X.-L. Xu, J. Chen, L. Zhu and J.G. Jiang, (2014) Preparation and physicochemical characteristics of an allicin nanoliposome and its release behavior. LWT - Food Science and Technology, 57, 686-695.
[21] Q. Lu, D.-C. Li and J.-G. Jiang, (2011) Preparation of a Tea Polyphenol Nanoliposome System and Its Physicochemical Properties. Journal of Agricultural and Food Chemistry, 59, 13004-13011.
[22] Andrade, J., C. González-Martínez and A. Chiralt, (2021) Liposomal Encapsulation of Carvacrol to Obtain Active Poly (Vinyl Alcohol) Films. Molecules, 26, 1589.
[23] A. Olad, H. Zebhi, D. Salari, A. Mirmohseni and A. Reyhanitabar, (2018) Water retention and slow release studies of salep-based hydrogel nanocomposite reinforced with montmorillonite clay. New Journal of Chemistry, 42, 2758.
[24] D.C. Montgomery, (2019) Experimental Designs for Fitting Response Surfaces, in Design and analysis of experiments. John wiley & sons: Arizona state university. 8st Ed.p. 430-476.
[25] A.D. Sezer, (2014) Liposomes as Potential Drug Carrier Systems for Drug Delivery.,Application of Nanotechnology in Drug Delivery, 1st Ed. pp.20.
[26] M. Nasrolahi and z. talebi, (2010) Salt sensitivity, pH responsivity and kinetic study of chitosan-g-PAA hydrogel. Applied Chemistry, 5(16), 31-42.
[27] A. Roy, K. Roy, S. Roy, J. Deb, A. Ghosh, and K.A. Ali, (2012) Response surface optimization of sustained release metformin-hydrochloride matrix tablets: influence of some hydrophillic polymers on the release. ISRN pharmaceutics, 2012 ,364261.
[28] G. Singhvi and M. Singh, (2011) Review: In vitro Drug Release Characterization Models. International Journal of Pharmaceutical Studies and Research, 2, 77-84.
[29] P. Costa and J.M. Sousa Lobo, (2001) Modeling and comparison of dissolution profiles. European Journal of Pharmaceutical Sciences, 13,123-133.
[30] C. Corsaro, G. Neri, A.M. Mezzasalma and E. Fazio, Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems. Polymers. Polymers, 13 (2021) 2897.
[31] C. Mircioiu, V. Voicu, V. Anuta, A. Tudose, C. Celia, D. Paolino, M. Fresta, R. Sandulovici, and I. Mircioiu, (2019) Mathematical Modeling of Release Kinetics from Supramolecular Drug Delivery Systems. Pharmaceutics, 11(3) 140. | ||
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