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Ranjbaran, Mohadese, Tavakoli, Mohammad Hossein, Keshtpour Amlashi, Zahra, Nikzad, Safoora. (1404). Influence of Coil Geometry on Magnetic Nanoparticle Hyperthermia in the Treatment of Peritoneal Metastasis. هنرهای کاربردی, 12(2), 413-427. doi: 10.22075/jhmtr.2025.36686.1677
Mohadese Ranjbaran; Mohammad Hossein Tavakoli; Zahra Keshtpour Amlashi; Safoora Nikzad. "Influence of Coil Geometry on Magnetic Nanoparticle Hyperthermia in the Treatment of Peritoneal Metastasis". هنرهای کاربردی, 12, 2, 1404, 413-427. doi: 10.22075/jhmtr.2025.36686.1677
Ranjbaran, Mohadese, Tavakoli, Mohammad Hossein, Keshtpour Amlashi, Zahra, Nikzad, Safoora. (1404). 'Influence of Coil Geometry on Magnetic Nanoparticle Hyperthermia in the Treatment of Peritoneal Metastasis', هنرهای کاربردی, 12(2), pp. 413-427. doi: 10.22075/jhmtr.2025.36686.1677
Ranjbaran, Mohadese, Tavakoli, Mohammad Hossein, Keshtpour Amlashi, Zahra, Nikzad, Safoora. Influence of Coil Geometry on Magnetic Nanoparticle Hyperthermia in the Treatment of Peritoneal Metastasis. هنرهای کاربردی, 1404; 12(2): 413-427. doi: 10.22075/jhmtr.2025.36686.1677

Influence of Coil Geometry on Magnetic Nanoparticle Hyperthermia in the Treatment of Peritoneal Metastasis

Journal of Heat and Mass Transfer Research
دوره 12، شماره 2 - شماره پیاپی 24، بهمن 2025، صفحه 413-427    اصل مقاله (1.89 M)
نوع مقاله: Full Length Research Article
شناسه دیجیتال (DOI): 10.22075/jhmtr.2025.36686.1677
نویسندگان
Mohadese Ranjbaran1؛ Mohammad Hossein Tavakoli* 1؛ Zahra Keshtpour Amlashi2؛ Safoora Nikzad3
1Department of Physics, Faculty of Science, Bu-Ali Sina University, Hamadan, Iran
2Cancer Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3Department of Medical Physics, Faculty of Medicine Isfahan University of Medical Sciences, Isfahan, Iran
تاریخ دریافت: 05 بهمن 1403،  تاریخ بازنگری: 14 اسفند 1403،  تاریخ پذیرش: 14 فروردین 1404 
چکیده
This study examines the impact of magnetic hyperthermia on treating peritoneal metastasis and analyzes the effect of coil geometry. The aim is to evaluate the efficacy of localized heating in eliminating cancer cells while preserving healthy tissue, with a specific focus on the influence of coil geometry on magnetic nanoparticle hyperthermia for treating peritoneal metastasis. Magnetic nanoparticles concentrate heat within the tumor, minimizing damage to surrounding tissues. Magnetic nanoparticles Fe3O4 were used to raise tumor temperatures to 42–46°C under an alternating magnetic field. A numerical simulation based on the finite element method was conducted to assess the effects of coil geometry and tumor location on heat transfer. The magnetic field distribution was calculated using Maxwell’s equations, while heat generation by nanoparticles was determined through Rosensweig’s theory. The Pennes bio-heat transfer equation was then applied to evaluate temperature distribution in both tumor and healthy tissues. The findings indicate that coil geometry significantly affects the distribution of the magnetic field, heat, and temperature. Cylindrical, flat, conical, and inverted conical coils generate the lowest overall heat while ensuring even distribution, leading to minimal temperature variations across the tumor. Therefore, these coils produce a more uniform temperature distribution within gastric tumors and peritoneal metastases. Additionally, they achieve the therapeutic temperature range required for cancer treatment. The temperature in healthy tissue remains around 37°C, confirming the absence of damage. Therefore, the aforementioned coils are the most suitable for use in magnetic hyperthermia as a treatment for gastric cancer and peritoneal metastasis.
کلیدواژه‌ها
Magnetic hyperthermia؛ Magnetic nanoparticles؛ Magnetic field؛ Peritoneal metastasis؛ Coil geometry؛ Bio-heat transfer
عنوان مقاله [English]
تاثیر هندسه پیچه بر گرمادرمانی نانوذرات مغناطیسی در درمان متاستاز صفاقی
چکیده [English]
هدف: این مطالعه به بررسی تاثیر گرمادرمانی مغناطیسی بر درمان متاستاز صفاقی و تجزیه و تحلیل اثر هندسه پیچه می پردازد. هدف ارزیابی کارایی گرمایش موضعی در از بین بردن سلول‌های سرطانی در حین حفظ بافت سالم، با تمرکز ویژه بر تأثیر هندسه پیچه بر گرمادرمانی نانوذرات مغناطیسی برای درمان متاستاز صفاقی است. نانوذرات مغناطیسی گرما را در تومور متمرکز کرده و آسیب به بافت‌های اطراف را به حداقل می‌رسانند.

روش: نانوذرات مغناطیسی Fe3O4 برای افزایش دمای تومور به 42-46 درجه سانتیگراد تحت یک میدان مغناطیسی متناوب استفاده شد. یک شبیه‌سازی عددی بر اساس روش اجزای محدود برای ارزیابی اثرات هندسه سیم پیچ و مکان تومور بر انتقال حرارت انجام شده و توزیع میدان مغناطیسی با استفاده از معادلات ماکسول، تولید گرما توسط نانوذرات از طریق نظریه روزنسویگ تعیین شد. سپس معادله انتقال حرارت زیستی Pennes برای ارزیابی توزیع دما در تومور و بافت سالم اعمال گردید.

یافته ها: یافته ها نشان می دهد که هندسه پیچه به طور قابل توجهی بر توزیع میدان مغناطیسی، گرما و دما تأثیر می گذارد. پیچه‌های مخروطی استوانه‌ای، مسطح، مخروطی و معکوس، کمترین گرمای کلی را همزمان با توزیع یکنواخت تر دما ایجاد می‌کنند. علاوه بر این، آنها به محدوده دمای درمانی مورد نیاز برای درمان سرطان دست می یابند. دما در بافت سالم در حدود 37 درجه سانتیگراد باقی مانده و عدم وجود آسیب را تأیید می کند. بنابراین، پیچه های فوق مناسب ترین هندسه برای استفاده در گرمادرمانی مغناطیسی به عنوان درمان سرطان معده و متاستاز صفاقی هستند.
کلیدواژه‌ها [English]
گرمادرمانی مغناطیسی, نانوذرات مغناطیسی, میدان مغناطیسی, متاستاز صفاقی, هندسه پیچه, انتقال حرارت زیستی
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