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Makvand-Hosseini, Shahrokh, Sedighi, Fariba, Yousefi, Mohammad Hassan. (1393). Animal Model of PTSD: behavioral changes following underwater trauma, situational reminders and diazepam treatment. نشریه هنرهای کاربردی, 1(1), 25-32. doi: 10.22075/ijce.2013.136
Shahrokh Makvand-Hosseini; Fariba Sedighi; Mohammad Hassan Yousefi. "Animal Model of PTSD: behavioral changes following underwater trauma, situational reminders and diazepam treatment". نشریه هنرهای کاربردی, 1, 1, 1393, 25-32. doi: 10.22075/ijce.2013.136
Makvand-Hosseini, Shahrokh, Sedighi, Fariba, Yousefi, Mohammad Hassan. (1393). 'Animal Model of PTSD: behavioral changes following underwater trauma, situational reminders and diazepam treatment', نشریه هنرهای کاربردی, 1(1), pp. 25-32. doi: 10.22075/ijce.2013.136
Makvand-Hosseini, Shahrokh, Sedighi, Fariba, Yousefi, Mohammad Hassan. Animal Model of PTSD: behavioral changes following underwater trauma, situational reminders and diazepam treatment. نشریه هنرهای کاربردی, 1393; 1(1): 25-32. doi: 10.22075/ijce.2013.136

Animal Model of PTSD: behavioral changes following underwater trauma, situational reminders and diazepam treatment

Iranian Journal Of Cognition And Education
مقاله 4، دوره 1، شماره 1، اسفند 2014، صفحه 25-32    اصل مقاله (166.72 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22075/ijce.2013.136
نویسندگان
Shahrokh Makvand-Hosseini* 1؛ Fariba Sedighi2؛ Mohammad Hassan Yousefi3
1SemnanUniversity
2Islamic Azad University
3Shahid Beheshti University of medical sciences
تاریخ دریافت: 20 شهریور 1392،  تاریخ بازنگری: 05 دی 1392،  تاریخ پذیرش: 07 اردیبهشت 1393 
چکیده
Objectives: The main purpose of this experimental research was to create an animal model of PTSD based on the main features of the disorder: trauma exposure, situational reminders (SR), behavioral anxiety and remedy in response to anxiolytic medications. Method: 6 inbred female Sprague-Dawley rats were obtained and evaluated in the elevated plus-maze test in 3 stages: 1- baseline 2- underwater trauma and SR 3- SR and diazepam (0/5 mg/kg) treatment. Measures of open arm ratio time and ratio entry were extracted from five days 5 minute video recordings for every stage and analyzed using repeated measures statistical analysis (GLM). Results: Results showed significant differences between the baseline and stage 2 and between stage 2 and 3. No significant difference was found between baseline and stage 3. These results indicated that a single underwater stress, together with daily SR exposure, successfully induced PTSD symptoms in rats. Subsequently, anxiolytic drug injection decreased the behavioral symptoms as well. Conclusion: Overall, our findings suggested underwater trauma, situational reminders and low dose diazepam injection in rats as a valid paradigm for PTSD modeling.
کلیدواژه‌ها
PTSD modeling؛ underwater trauma؛ situational reminders؛ diazepam treatment
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